Joint EMERGE - PReS-Working-party Autoinflammation fellowship

For the year 2021 two different fellowship programs will be available. 

  1.     Open fellowship for clinicians and/or scientists (1 place) - Bring me there;
  2.     Joint fellowship with autoinflammatory working party (1 place) - See below;

Project Title:

Fostering patient registries as platforms for future epidemiological, clinical and translational research

This program is aimed at paediatric rheumatology trainees and young scientists who are members of PReS and younger than 45 years, allowing them to visit Pediatric rheumatology training centres in Muenster (Germany), Lausanne (Switzerland) and Genoa (Italy) for the period of up to 6 months.

 

About the project:

Investigators

AID team: Dirk Föll, Helmut Wittkowski

JIR team: Veronique Hentgen, Michael Hofer, Francois Hofer
Eurofever team: Marco Gattorno, Ricardo Papa, Eugenia Mosci, Roberta Caorsi

 

Background:

Hereditary recurrent fever syndromes (HPF) are very rare autoinflammatory diseases (AID). They are characterized by recurrent, self-limiting, systemic inflammatory reactions and are associated with a dysregulation of the innate immune system. HPF are characterized by their symptoms (fever, serositis, joint, abdominal and skin involvement, etc.) and, if available, a positive mutation analysis and can lead to serious complications such as amyloidosis. Among the genetically determined fever syndromes, Familial Mediterranean Fever (FMF) is relatively frequent and therefore of particular importance.

For other clinically defined AID, no genetic background is known to date. There are several more or less well characterized Systemic Autoinflammatory Diseases (SAID), which include also PFAPA syndrome (periodic fever with aphthae, pharyngitis, adenitis) and SURF syndrome (Systemic Undifferentiated Recurring Fever). The most important defined syndromes without monogenetic cause also include systemic juvenile Idiopathic arthritis (SJIA), also known as Still's syndrome. Many patients experience years of delay in diagnosis. The low incidence of AID makes it difficult to evaluate therapies and prognosis. Therefore, exploitation of data collected into registries is key to improve our knowledge.

In particular, changes in diagnosis making and the use of colchicine, steroids and biologicals over time can be analyzed. Furthermore, a comparison of the patient groups in the years 2009-2013 with 2014-2018 can be planned. The combined efforts of the EUROFEVER database, the JIR cohort and the German AID registry enables us to make a Europe-wide comparison of patient groups. Different therapies and the prediction of outcomes such as complications and damage will be taken into account.

 

Main Project Objective

In a project supported/endorsed by the PReS Working Party on Autoinflammatory Diseases and in conjunction with the Metadata registry for the ERN RITA (MERITA) project, we aim at performing data harmonization and comparative analyses of selected most relevant research questions. This is also meant to improve further work in the registries.

 

Figure 1. Example of a items that can be analyzed with regard to changes over time, e.g. by comparing data from patients collected early versus later.

 

Tasks for the EMERGE fellow

For this project, we are looking for a researcher/pediatric rheumatology fellow who should coordinate the analyses including rotations to the involved centers in Genoa, Lausanne and Muenster and should care for the report.

 

PROGRAM FINANCING:

  • Each bursary includes 2,000 euro for travel assistance and 2,000 euro per month for living expenses (total of 14,000 euro for six months);

PROGRAM DEADLINES:

  1. Program will be announced in February 2021;
  2. Application deadline will be 1st of April 2021
  3. Selected candidates would be announced by the end of April 2021
  4. The fellowship should begin in June 2021

How to apply?

  • The application deadline is 1st of April 2021, and one place will be available;
  • Applications and queries related to the PReS EMERGE fellowship programme should be directed to:  emerge.pres@gmail.com

Each candidate must complete and submit:

  • A standardised trainee questionnaire (see links below for trainee questionnaires for paediatric rheumatology trainees or young scientists)
  • A short CV
  • A personal statement supporting the application
  • The candidates, if more than one, will be judged by the programme coordinators, based on the application form. If a member of the coordinating team has a potential conflict of interest in a particular application, she/he will not participate in the judging of that application.
  • The selected candidate will be announced within one month of the application deadline.
  • If the candidate chosen for the fellowship cannot take up their place in the programme, the next candidate on the list will be considered.

PROGRAM COORDINATORS:

  1. Prof Sefi Uziel (PRES council)
  2. Prof Fabrizio De Benedetti (PRES council)
  3. Prof Jordi Anton Lopez (PRES council)
  4. Lovro Lamot (PRES council and EMERGE group)
  5. Eve Smith (EMERGE group)
  6. Dirk Foell (Autoinflammatory Working Party)
  7. Veronique Hentgen (Autoinflammatory Working Party)
  8. Michael Hofer (JIRcohort coordinator)
  9. Marco Gattorno (EUROFEVER coordinator)

Go to Fellowship for clinicians and/or scientists

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